| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[[7-(2,6-difluorophenyl)-5,6,7,8-tetrahydro-5,8-dimethyl-6-oxo-2-pteridinyl]amino]- | [CAS]
2414484-01-6 | [Synonyms]
Benzenesulfonamide, 4-[[7-(2,6-difluorophenyl)-5,6,7,8-tetrahydro-5,8-dimethyl-6-oxo-2-pteridinyl]amino]- | [Molecular Formula]
C20H18F2N6O3S | [MOL File]
2414484-01-6.mol | [Molecular Weight]
460.46 |
| Chemical Properties | Back Directory | [Boiling point ]
713.8±70.0 °C(predicted) | [density ]
1.490±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.77±0.12(predicted) |
| Hazard Information | Back Directory | [Uses]
IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42 nM and 109 nM, for MST1 and MST2. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 ameliorates diabetes in Streptozotocin (HY-13753)-induced type 1 diabetes (T1D) mouse models[1]. |
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