| Identification | Back Directory | [Name]
Ethanone, 1-[5-[[4-[3-fluoro-5-(trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]-2,3-dihydro-1H-indol-1-yl]- | [CAS]
2414592-36-0 | [Synonyms]
JH-LPH-28
Ethanone, 1-[5-[[4-[3-fluoro-5-(trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]-2,3-dihydro-1H-indol-1-yl]- | [Molecular Formula]
C21H21F4N3O3S | [MOL File]
2414592-36-0.mol | [Molecular Weight]
471.47 |
| Chemical Properties | Back Directory | [Boiling point ]
663.1±65.0 °C(Predicted) | [density ]
1.432±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.39±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL[1]. | [References]
[1] Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116. DOI:10.1073/pnas.1912876117 |
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