| Identification | Back Directory | [Name]
2H-1-Benzopyran-2-one, 4-methyl-7-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methoxy]- | [CAS]
2414629-94-8 | [Synonyms]
hCAIX/XII-IN-3
2H-1-Benzopyran-2-one, 4-methyl-7-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methoxy]- | [Molecular Formula]
C20H13F3N2O4 | [MOL File]
2414629-94-8.mol | [Molecular Weight]
402.32 |
| Hazard Information | Back Directory | [Uses]
hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1]. | [References]
[1] Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739. DOI:10.1016/j.bioorg.2020.103739 |
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