| Identification | Back Directory | [Name]
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- | [CAS]
2414633-49-9 | [Synonyms]
CDK1/2/4-IN-1
2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)- | [Molecular Formula]
C15H16N2O2S | [MOL File]
2414633-49-9.mol | [Molecular Weight]
288.36 |
| Hazard Information | Back Directory | [Uses]
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1]. | [IC 50]
CDK2: 0.78 (IC50); CDK4: 0.87 (IC50); CDK1: 1.47 (IC50); Caspase 3; Bax; Bcl-2 | [References]
[1] Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761. DOI:10.1016/j.bioorg.2020.103761 |
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