| Identification | Back Directory | [Name]
suvn-911 | [CAS]
2414674-71-6 | [Synonyms]
suvn-911
SUVN-911(compound 9h)
nicotinic,antidepressant,nAChR,acetylcholine,neuronal,Inhibitor,SUVN-911,suvn911,suvn 911,depression,inhibit,Nicotinic acetylcholine receptors | [Molecular Formula]
C11H14Cl2N2O | [MDL Number]
MFCD32689655 | [MOL File]
2414674-71-6.mol | [Molecular Weight]
261.15 |
| Hazard Information | Back Directory | [Uses]
SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1]. | [in vivo]
SUVN-911 is devoid of cardiovascular and gastrointestinal side effects[1].
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects[1].
SUVN-911 shows metabolic stability in rats[1].
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats[1].
| Animal Model: | Male Wistar rats (180-230 g)[1] | | Dosage: | 1 mg/kg, 3 mg/kg, 10.0 mg/kg | | Administration: | Oral administration, daily, for 3 days | | Result: | Showed antidepressant like activity with no signs of tachyphylaxis. |
| Animal Model: | Male Wistar rats (225 ± 25 g)[1] | | Dosage: | 3 mg/kg (Pharmacokinetic Analysis) | | Administration: | Oral administration | | Result: | AUC=3507 ng*h/mL, T1/2=3.34 hours. |
| [References]
[1] Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853. DOI:10.1021/acs.jmedchem.9b00790 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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