| Identification | Back Directory | [Name]
1,2,4-Triazine-6-carboxamide, N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-3-fluorophenyl]-2,3,4,5-tetrahydro-4-methyl-3,5-dioxo-2-phenyl- | [CAS]
2415291-03-9 | [Synonyms]
c-Met-IN-10
1,2,4-Triazine-6-carboxamide, N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-3-fluorophenyl]-2,3,4,5-tetrahydro-4-methyl-3,5-dioxo-2-phenyl- | [Molecular Formula]
C26H21FN6O5 | [MOL File]
2415291-03-9.mol | [Molecular Weight]
516.48 |
| Hazard Information | Back Directory | [Uses]
c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29?cells, induces HT-29 and A549?cells apoptosis, and inhibits A549?cells motility. c-Met-IN-10 can be used for researching anticancer[1]. | [References]
[1] Liu J, et al. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244. DOI:10.1016/j.ejmech.2020.112244 |
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