| Identification | Back Directory | [Name]
Azido-dPEG???-OH | [CAS]
2415674-94-9 | [Synonyms]
Azido-dPEG24-OH
N3-PEG24-OH/71-Azido-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-tricosaoxahenheptacontan-1-ol | [Molecular Formula]
C48H97N3O24 | [MOL File]
2415674-94-9.mol | [Molecular Weight]
1100.3 |
| Hazard Information | Back Directory | [Uses]
Azido-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG24-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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