| Identification | Back Directory | [Name]
Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-, hydrochloride (1:1) | [CAS]
2416146-10-4 | [Synonyms]
NAcM-OPT hydrochloride
NAcM-OPT HCl(2089293-61-6 free base)
NAcM-OPT HCl(2089293-61-6 free base), 10 mM in DMSO
NAcMOPT HCl(2089293616 free base),NAcM OPT HCl(2089293 61 6 free base)
1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea hydrochloride
Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-, hydrochloride (1:1) | [Molecular Formula]
C23H30Cl3N3O | [MOL File]
2416146-10-4.mol | [Molecular Weight]
470.86 |
| Hazard Information | Back Directory | [Uses]
NAcM-OPT (hydrochloride) is a protein interaction inhibitor. NAcM-OPT (hydrochloride) can disrupt the interaction between DCN1 and UBC12, with an IC50 value of 80 nM. NAcM-OPT (hydrochloride) can protect keratinocytes from H2O2-induced cell damage by promoting autophagy[1][2]. | [References]
[1] Fang Y, et al. Targeting the DCN1-UBC12 protein-protein interaction: novel approaches and future directions. Future Med Chem. 2019 Nov;11(22):2869-2871. DOI:10.4155/fmc-2019-0253
[2] Xiong R, et al. NAcM-OPT protects keratinocytes from H2O2-induced cell damage by promoting autophagy. Ann N Y Acad Sci. 2024 Jul;1537(1):155-167. DOI:10.1111/nyas.15173 |
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