| Identification | Back Directory | [Name]
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-[[5-(methoxymethyl)-2-furanyl]methylene]-, (3Z,6Z)- | [CAS]
2416338-64-0 | [Synonyms]
Microtubule inhibitor 6
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-[[5-(methoxymethyl)-2-furanyl]methylene]-, (3Z,6Z)- | [Molecular Formula]
C24H19FN2O5 | [MOL File]
2416338-64-0.mol | [Molecular Weight]
434.42 |
| Hazard Information | Back Directory | [Uses]
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1]. | [References]
[1] Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435. DOI:10.1016/j.bmc.2020.115435 |
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