| Identification | Back Directory | [Name]
2H-1-Benzopyran-3-carboxylic acid, 6-chloro-2-oxo-, (4-chlorophenyl)(4,5-dimethyl-2-thiazolyl)methyl ester | [CAS]
2416400-32-1 | [Synonyms]
DNA Gyrase-IN-4
2H-1-Benzopyran-3-carboxylic acid, 6-chloro-2-oxo-, (4-chlorophenyl)(4,5-dimethyl-2-thiazolyl)methyl ester | [Molecular Formula]
C22H15Cl2NO4S | [MOL File]
2416400-32-1.mol | [Molecular Weight]
460.33 |
| Hazard Information | Back Directory | [Uses]
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively[1]. | [References]
[1] Liu H, et al. Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity. Bioorg Chem. 2020 Jul;100:103907. DOI:10.1016/j.bioorg.2020.103907 |
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