| Identification | Back Directory | [Name]
1-Piperazinecarboxamide, N-(5-chloro-2-thiazolyl)-4-(5,6-dichloro-3-pyridinyl)- | [CAS]
2416971-32-7 | [Synonyms]
HIV-1 inhibitor-35
1-Piperazinecarboxamide, N-(5-chloro-2-thiazolyl)-4-(5,6-dichloro-3-pyridinyl)- | [Molecular Formula]
C13H12Cl3N5OS | [MOL File]
2416971-32-7.mol | [Molecular Weight]
392.69 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-35 (compound 74) is a potent HIV-1 inhibitor with EC50s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC50 of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent[1]. | [References]
[1] Nguyen W, et al. Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents. Eur J Med Chem. 2020;195:112254. DOI:10.1016/j.ejmech.2020.112254 |
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