| Identification | Back Directory | [Name]
Sulfamide, N-[2-fluoro-3-[[4-methyl-7-[3-[[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yl]oxy]propoxy]-2-oxo-2H-1-benzopyran-3-yl]methyl]phenyl]-N'-methyl- | [CAS]
2417022-06-9 | [Synonyms]
MEK-IN-5
Sulfamide, N-[2-fluoro-3-[[4-methyl-7-[3-[[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yl]oxy]propoxy]-2-oxo-2H-1-benzopyran-3-yl]methyl]phenyl]-N'-methyl- | [Molecular Formula]
C29H27FN4O10S2 | [MOL File]
2417022-06-9.mol | [Molecular Weight]
674.67 |
| Hazard Information | Back Directory | [Uses]
MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1]. | [References]
[1] Wang C, et al. Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs. Eur J Med Chem. 2020; 196:112271. DOI:10.1016/j.ejmech.2020.112271 |
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