| Identification | Back Directory | [Name]
Thieno[3,2-d]pyrimidine-6-methanamine, 2,4-di-4-morpholinyl-N-3H-1,2,4-triazol-5-yl- | [CAS]
2417098-53-2 | [Synonyms]
PI3Kα-IN-7
Thieno[3,2-d]pyrimidine-6-methanamine, 2,4-di-4-morpholinyl-N-3H-1,2,4-triazol-5-yl- | [Molecular Formula]
C17H22N8O2S | [MOL File]
2417098-53-2.mol | [Molecular Weight]
402.47 |
| Hazard Information | Back Directory | [Uses]
PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1]. | [IC 50]
PI3Kα; PI3Kβ | [References]
[1] Ye T, et al. Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents. Bioorg Chem. 2020 Jun;99:103796. DOI:10.1016/j.bioorg.2020.103796 |
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