| Identification | Back Directory | [Name]
N-[4-[[2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino]-5-(1-oxopropyl)-2-pyridinyl]cyclopropanecarboxamide | [CAS]
2417134-93-9 | [Synonyms]
N-[4-[[2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino]-5-(1-oxopropyl)-2-pyridinyl]cyclopropanecarboxamide | [Molecular Formula]
C22H24N6O3 | [MOL File]
2417134-93-9.mol | [Molecular Weight]
420.47 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
12.67±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
JAK-IN-26 (compound 2) is an orally active JAK inhibitor with good pharmacokinetic characteristics. JAK-IN-26 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=17.2 nM)[1]. | [References]
[1] Zhou M, et al. Pyridine derivatives as TYK2 kinase inhibitors and preparation thereof. China, CN113563309 A 2021-10-29. |
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