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FFA1 agonist-1 (Compound 17a) is an orally active fatty acid receptor 1 (FFA1) agonist with an EC50 of 0.75 μM. FFA1 agonist-1 can be used for type 2 diabetes mellitus research[1]. | [in vivo]
FFA1 agonist-1 (Compound 17a) (0-25 mg/kg; p.o.) reduces the plasma glucose levels in a dose-dependent manner in mice[1]. | [References]
[1] Kuranov SO, et al. Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40). Bioorg Chem. 2020 Jun;99:103830. DOI:10.1016/j.bioorg.2020.103830 |
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