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2417370-71-7

2417370-71-7 Structure

2417370-71-7 Structure
IdentificationBack Directory
[Name]

PROTAC BRD4 Degrader-13
[CAS]

2417370-71-7
[Synonyms]

PROTAC BRD4 Degrader-13
{[(3R,5S)-1-[(2S)-2-(11-{[8-(3,5-difluoropyridin-2-yl)-4-(methanesulfonylmethyl)-15-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,?.013,1?]heptadeca-1(16),2,4,6,10,13(17)-hexaen-5-yl]formamido}undecanamido)-3,3-dimethylbutanoyl]-5-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-3-yl]oxy}[({2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]ethoxy}(hydroxy)phosphoryl)oxy]phosphinic acid
[Molecular Formula]

C68H85F2N11O17P2S2
[MOL File]

2417370-71-7.mol
[Molecular Weight]

1492.55
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[pka]

1.14±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50 values ??of 0.025 nM and 6.0 nM, respectively[1].
[References]

[1] Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. DOI:10.1021/acs.jmedchem.0c01846
2417370-71-7 suppliers list
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Website: https://www.wodapro.com
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
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