| Identification | Back Directory | [Name]
2-Propenamide, 2-cyano-N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-3-(ethylamino)-3-(ethylthio)-, (2E)- | [CAS]
2418026-70-5 | [Synonyms]
Dihydropteroate synthase-IN-1
2-Propenamide, 2-cyano-N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-3-(ethylamino)-3-(ethylthio)-, (2E)- | [Molecular Formula]
C19H23N5O4S2 | [MOL File]
2418026-70-5.mol | [Molecular Weight]
449.55 |
| Hazard Information | Back Directory | [Uses]
Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material[1]. | [References]
[1] Nasr T, et al. New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors. Bioorg Med Chem. 2020 May 1;28(9):115444. DOI:10.1016/j.bmc.2020.115444 |
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