| Identification | Back Directory | [Name]
Cyclopentaneacetamide, α-[[[3,5-bis(trifluoromethyl)phenyl]methyl]thio]- | [CAS]
2418576-06-2 | [Synonyms]
mEH-IN-1
Cyclopentaneacetamide, α-[[[3,5-bis(trifluoromethyl)phenyl]methyl]thio]- | [Molecular Formula]
C16H17F6NOS | [MOL File]
2418576-06-2.mol | [Molecular Weight]
385.37 |
| Chemical Properties | Back Directory | [Boiling point ]
395.4±42.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
15.73±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer[1]. | [References]
[1] Bogdan Barnych, et al. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem. 2020 May 1;193:112206. DOI:10.1016/j.ejmech.2020.112206 |
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