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2418576-06-2

2418576-06-2 Structure

2418576-06-2 Structure
IdentificationBack Directory
[Name]

Cyclopentaneacetamide, α-[[[3,5-bis(trifluoromethyl)phenyl]methyl]thio]-
[CAS]

2418576-06-2
[Synonyms]

mEH-IN-1
Cyclopentaneacetamide, α-[[[3,5-bis(trifluoromethyl)phenyl]methyl]thio]-
[Molecular Formula]

C16H17F6NOS
[MOL File]

2418576-06-2.mol
[Molecular Weight]

385.37
Chemical PropertiesBack Directory
[Boiling point ]

395.4±42.0 °C(Predicted)
[density ]

1.360±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

15.73±0.50(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer[1].
[References]

[1] Bogdan Barnych, et al. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem. 2020 May 1;193:112206. DOI:10.1016/j.ejmech.2020.112206
2418576-06-2 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
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Tel: 021-13816613772 13816613772
Website: www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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