| Identification | Back Directory | [Name]
Benzenesulfonamide, N-[(1R,2R)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- | [CAS]
2418594-00-8 | [Synonyms]
2418594-00-8
Benzenesulfonamide, N-[(1R,2R)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- | [Molecular Formula]
C23H31N3O3S | [MOL File]
2418594-00-8.mol | [Molecular Weight]
429.58 |
| Hazard Information | Back Directory | [Biological Activity]
(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3[1]. | [References]
[1]. Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966. |
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