| Identification | Back Directory | [Name]
1H-Imidazole, 1-[2-[[(2,4-dichlorophenyl)methyl]seleno]-2-(2,4-difluorophenyl)ethyl]- | [CAS]
2422019-91-6 | [Synonyms]
Antifungal agent 30
1H-Imidazole, 1-[2-[[(2,4-dichlorophenyl)methyl]seleno]-2-(2,4-difluorophenyl)ethyl]- | [Molecular Formula]
C18H14Cl2F2N2Se | [MOL File]
2422019-91-6.mol | [Molecular Weight]
446.18 |
| Hazard Information | Back Directory | [Uses]
Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51[1]. | [References]
[1] Xu H, et al. Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. Eur J Med Chem. 2020 Jul 15;198:112360. DOI:10.1016/j.ejmech.2020.112360 |
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