| Identification | Back Directory | [Name]
1H-Pyrrole-3-carboxamide, 1-(1,1-dimethylethyl)-N-[2-[[4-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-2-oxoethyl]-, rel- | [CAS]
2422030-94-0 | [Synonyms]
BRM/BRG1 ATP Inhibitor-4
1H-Pyrrole-3-carboxamide, 1-(1,1-dimethylethyl)-N-[2-[[4-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-2-oxoethyl]-, rel- | [Molecular Formula]
C25H32N6O3S | [MOL File]
2422030-94-0.mol | [Molecular Weight]
496.62 |
| Hazard Information | Back Directory | [Uses]
BRM/BRG1 ATP Inhibitor-4 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-4 can be used for the research of cancers and BAF complex-related disorders[1]. | [in vivo]
BRM/BRG1 ATP Inhibitor-4 (QD; 5, 15, 50 mg/kg) leds to tumor growth inhibition in a dose-dependent manner[1]. | Animal Model: | Nude mice[1] | | Dosage: | 5, 15, 50 mg/kg | | Administration: | QD | | Result: | Inhibited tumor growth and the size of tumors in mice engrafted with uveal melanoma cell lines. |
| [References]
[1] Kevin J. Wilson, et al. Compounds and uses thereof. Patent. WO2021155320A1. |
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