| Chemical Properties | Back Directory | [Boiling point ]
958.907±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.432±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
3.073±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
FXIa-IN-14 (Compound 14c) is a FXIa inhibitor with an IC50 value of 15 nM[1]. | [References]
[1] Wang Y, et al. Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors. Bioorg Med Chem Lett. 2024 Jan 9;99:129610. DOI:10.1016/j.bmcl.2024.129610
[2] Wang Y, et al. Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 99: 129610. DOI:10.1016/j.bmcl.2024.129610 |
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