| Identification | Back Directory | [Name]
Hydrazinecarbothioamide, 2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]-N-phenyl-, (2E)- | [CAS]
2426686-17-9 | [Synonyms]
Anticancer agent 46
Hydrazinecarbothioamide, 2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]-N-phenyl-, (2E)- | [Molecular Formula]
C15H14ClN3OS | [MOL File]
2426686-17-9.mol | [Molecular Weight]
319.81 |
| Chemical Properties | Back Directory | [Boiling point ]
466.0±55.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.15±0.43(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 46 (compound 2) is a potent anticancer agent. Anticancer agent 46 shows antiproliferative activity with an IC50 of 0.986 μM for MGC803 cells. Anticancer agent 46 has the potential for the research of gastric cancer[1]. | [References]
[1] Zhang XH, et al. Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents. Eur J Med Chem. 2020 Aug 1;199:112349. DOI:10.1016/j.ejmech.2020.112349 |
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