| Identification | Back Directory | [Name]
2,5-Pyridinedicarboxylic acid, 1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo- | [CAS]
2428387-82-8 | [Synonyms]
COX-1/2-IN-3
2,5-Pyridinedicarboxylic acid, 1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo- | [Molecular Formula]
C14H8N2O8 | [MOL File]
2428387-82-8.mol | [Molecular Weight]
332.22 |
| Hazard Information | Back Directory | [Uses]
COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity[1]. | [in vivo]
COX-1/2-IN-3 (Compound 7a) (1.25 and 0.625 mg/ear) exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity[1]. | [IC 50]
COX-1; COX-2 | [References]
[1] Gon?alves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549. DOI:10.1016/j.bmc.2020.115549 |
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