| Identification | Back Directory | [Name]
Thalidomide-4-NH-C10-COO(t-Bu) | [CAS]
2428400-25-1 | [Synonyms]
Thalidomide-4-NH-C10-COO(t-Bu)
2-(2,6-Dioxohexahydropyridin-3-yl)-4-(undecylamino)isoindole-1,3-dione |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958)[1]. | [References]
[1] Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity |
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