| Identification | Back Directory | [Name]
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- | [CAS]
2428423-77-0 | [Synonyms]
Chk1-IN-6
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- | [Molecular Formula]
C16H18F3N7 | [MOL File]
2428423-77-0.mol | [Molecular Weight]
365.36 |
| Chemical Properties | Back Directory | [Boiling point ]
569.9±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.01±0.25(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate. | [IC 50]
Chk1 | [References]
[1] Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090. DOI:10.1021/acs.jmedchem.1c00994 |
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