| Identification | Back Directory | [Name]
Benzenesulfonamide, N-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]- | [CAS]
2428743-04-6 | [Synonyms]
FGFR3-IN-1
Benzenesulfonamide, N-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]- | [Molecular Formula]
C28H39N9O3S | [MOL File]
2428743-04-6.mol | [Molecular Weight]
581.73 |
| Hazard Information | Back Directory | [Uses]
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor, with IC50s of 40 nM, 5.1 nM, and 12 nM for FGFR1, 2, and 3, respectively. FGFR3-IN-1 can be used for the research of bladder cancer[1]. | [IC 50]
FGFR1: 40 nM (IC50); FGFR2: 5.1 nM (IC50); FGFR3: 12 nM (IC50) | [References]
[1] Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453. DOI:10.1016/j.bmc.2020.115453 |
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