| Chemical Properties | Back Directory | [Boiling point ]
702.7±60.0 °C(predicted) | [density ]
1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.32±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1]. | [in vivo]
MNK1/2-IN-8 (compound 15b) inhibits tumor growth in xenograft model of lung cancer LL/2 cells in mice[1]. | [IC 50]
MNK1: 0.8 nM (IC50); MNK2: 1.5 nM (IC50) | [References]
[1] Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499. DOI:10.1016/j.ejmech.2024.116499 |
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