| Identification | Back Directory | [Name]
9-Phenanthrenemethanol, 9,10-dihydro-5-hydroxy-8-methyl-1-(4-phenyl-2-pyridinyl)-, 9-acetate | [CAS]
2432956-06-2 | [Synonyms]
3CPLro-IN-1
9-Phenanthrenemethanol, 9,10-dihydro-5-hydroxy-8-methyl-1-(4-phenyl-2-pyridinyl)-, 9-acetate | [Molecular Formula]
C29H25NO3 | [MOL File]
2432956-06-2.mol | [Molecular Weight]
435.52 |
| Hazard Information | Back Directory | [Uses]
3CPLro-IN-1 (compound A17) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 of 5.65 μM. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive agent target for fighting COVID-19[1]. | [References]
[1] Zhang JW, et al. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19. Eur J Med Chem. 2022;228:114030. DOI:10.1016/j.ejmech.2021.114030 |
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