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Bafisontamab (EMB-01) is a bispecific antibody targeting EGFR and cMET with antitumor activity[1]. | [in vivo]
Bafisontamab (EMB-01) induces significantly stronger anti-tumor activity in PDX and CDX tumor models than that of anti-EGFR mAb or anti-cMet mAb alone. Bafisontamab shows significant anti-tumor activity in anti-EGFR mAb resistant tumor model[1]. | [IC 50]
EGFR; c-Met | [References]
[1] Ren F, et al. EMB-01: An innovative bispecific antibody targeting EGFR and cMet on tumor cells mediates a novel mechanism to improve anti-tumor efficacy. Cancer Research, 2020, 80(16_Supplement): 528-528. |
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