| Identification | Back Directory | [Name]
H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH, (Disulfide bond) | [CAS]
244082-19-7 | [Synonyms]
CTT 1
CTTHWGFTLC(disulfidebond:1-10)
H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH, (Disulfide bond)
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
MMP-2/MMP-9 INHIBITOR III;MATRIX METALLOPROTEINASE-2/MATRIX METALLOPROTEINASE-9 INHIBITOR III
L-Cysteine, L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophylglycyl-L-phenylalanyl-L-threonyl-L-leucyl-, cyclic (1→10)-disulfide | [Molecular Formula]
C52H71N13O14S2 | [MDL Number]
MFCD18782259 | [MOL File]
244082-19-7.mol | [Molecular Weight]
1166.33 |
| Chemical Properties | Back Directory | [Boiling point ]
1667.887±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.284±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
2.956±0.70(predicted) | [Sequence]
Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys (Disulfide Bridge: Cys1-Cys10) |
| Hazard Information | Back Directory | [Uses]
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1]. | [in vivo]
CTTHWGFTLC, CYCLIC inhibits tumor progression in vivo, in mouse models[1]. | [IC 50]
MMP-2; MMP-9 | [References]
[1] Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85. PMID:11358815 |
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