| Identification | Back Directory | [Name]
PYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE | [CAS]
24410-19-3 | [Synonyms]
Pyrido[2,3-d]pyrimidin-4(...
3H-PYRIDO[2,3-D]PYRIMIDIN-4-ONE
Pyrido[2,3-d]pyrimidin-4(H)-one
PYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE
3-Aza-1,8-naphthyridine-4(3H)-one
1H,4H-pyrido[2,3-d]pyriMidin-4-one
3H,4H-pyrido[2,3-d]pyrimidin-4-one
3,4-Dihydropyrido[2,3-d]pyrimidine-4-one
Pyrido[2,3-d]pyrimidin-4(1H)-one (8CI,9CI)
PYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE ISO 9001：2015 REACH | [Molecular Formula]
C7H5N3O | [MDL Number]
MFCD08234707 | [MOL File]
24410-19-3.mol | [Molecular Weight]
147.13 |
| Chemical Properties | Back Directory | [Melting point ]
255-257 °C(Solv: water (7732-18-5)) | [Boiling point ]
346.2±34.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
1.32±0.20(Predicted) | [Appearance]
White to off-white Solid | [CAS DataBase Reference]
24410-19-3 |
| Hazard Information | Back Directory | [Synthesis]
In a 10 mL pressure-resistant stainless steel reactor, 1.00 g (7.2 mmol) of 2-aminonicotinic acid, 3.07 g (28.8 mmol) of trimethyl orthoformate and 5.0 mL (38 mmol) of 15 wt% ammonia-methanol solution were added and the reaction was carried out for 8 hr at 105 °C. After completion of the reaction, the reaction mixture was cooled to room temperature and concentrated under reduced pressure to afford 1.06 g (Yield: 100%) of 3H-pyrido[2,3-d]pyrimidin-4-one as a black solid. The product was characterized by the following data: 1H-NMR (DMSO-d6, δ/ppm): 3.36 (1H, brs), 7.46 (1H, dd, J = 8.0, 4.5 Hz), 8.31 (1H, s), 8.45 (1H, dd, J = 7.8, 2.1 Hz), 8.87 (1H, dd, J = 4.8, 2.1 Hz); CI- MS (m/e): 148 (M+1). | [References]
[1] Patent: EP1637523, 2006, A1. Location in patent: Page/Page column 8 |
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