| Identification | Back Directory | [Name]
1-Butanone, 4-(4-butyl-1-piperidinyl)-1-(2-methylphenyl)- | [CAS]
244291-63-2 | [Synonyms]
1-Butanone, 4-(4-butyl-1-piperidinyl)-1-(2-methylphenyl)- | [Molecular Formula]
C20H31NO | [MDL Number]
MFCD32200152 | [MOL File]
244291-63-2.mol | [Molecular Weight]
301.47 |
| Hazard Information | Back Directory | [Description]
AC-42 is an M1 muscarinic receptor allosteric agonist. | [Uses]
AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells[1][2]. | [References]
[1] Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. DOI:10.1124/mol.110.065771
[2] Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. DOI:10.1124/mol.105.017814 |
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