| Hazard Information | Back Directory | [Uses]
HDAC6-IN-33 (compound 6) is a selective and irreversible HDAC6 inhibitor with an IC50 of 193 nM. HDAC6-IN-33 shows no activity against HDAC1-4. HDAC6-IN-33 is a tight-binding HDAC6 inhibitor capable of inhibiting HDAC6 via a two-step slow-binding mechanism[1]. | [IC 50]
HDAC6: 193 nM (IC50) | [References]
[1] Beate K?nig, et al. Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6. J Med Chem. 2023 Oct 12;66(19):13821-13837. DOI:10.1021/acs.jmedchem.3c01345 |
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