| Identification | Back Directory | [Name]
Imidazo[1',2':1,6]pyrido[2,3-d]pyrimidine-6-carbonitrile, 2-amino-5,8-dimethyl- | [CAS]
2445205-24-1 | [Synonyms]
CDK4/6-IN-12
Imidazo[1',2':1,6]pyrido[2,3-d]pyrimidine-6-carbonitrile, 2-amino-5,8-dimethyl- | [Molecular Formula]
C12H10N6 | [MOL File]
2445205-24-1.mol | [Molecular Weight]
238.25 |
| Hazard Information | Back Directory | [Uses]
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1]. | [IC 50]
CDK4: 592.3 nM (IC50); CDK6: 3090 nM (IC50) | [References]
[1] Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239. DOI:10.1016/j.ejmech.2020.112239 |
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