| Identification | Back Directory | [Name]
2(1H)-Pyridinone, 5-[5-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methyl- | [CAS]
2445615-24-5 | [Synonyms]
A2A/A1 AR antagonist-1
2(1H)-Pyridinone, 5-[5-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methyl- | [Molecular Formula]
C15H12N6O2 | [MOL File]
2445615-24-5.mol | [Molecular Weight]
308.29 |
| Hazard Information | Back Directory | [Uses]
A2A/A1 AR antagonist-1 (compound 1a) is dual potent A2A/A1 AR antagonist with Kis of 5.58 and 24.2 nM, respectively. A2A/A1 AR antagonist-1 has the potential for the research of ischemic stroke[1]. | [References]
[1] Tang ML, et al. Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Med Chem Lett. 2022;13(3):436-442. Published 2022 Feb 21. DOI:10.1021/acsmedchemlett.1c00599 |
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