| Identification | Back Directory | [Name]
Benzaldehyde, 4-chloro-, 2-(5,6-diphenyl-1,2,4-triazin-3-yl)hydrazone, [C(E)]- | [CAS]
2446063-14-3 | [Synonyms]
α-Amylase/α-Glucosidase-IN-2
Benzaldehyde, 4-chloro-, 2-(5,6-diphenyl-1,2,4-triazin-3-yl)hydrazone, [C(E)]- | [Molecular Formula]
C22H16ClN5 | [MOL File]
2446063-14-3.mol | [Molecular Weight]
385.86 |
| Hazard Information | Back Directory | [Uses]
α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC50 values of 13.02, 13.09 μM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications[1]. | [References]
[1] Shamim S, et al. Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase. Bioorg Chem. 2020 Aug;101:103979. DOI:10.1016/j.bioorg.2020.103979 |
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