| Identification | Back Directory | [Name]
Luotonin F | [CAS]
244616-85-1 | [Synonyms]
Luotonin F
Luotonin F Exclusive
2-(quinoline-3-carbonyl)-1H-quinazolin-4-one | [Molecular Formula]
C18H11N3O2 | [MOL File]
244616-85-1.mol | [Molecular Weight]
301.3 |
| Chemical Properties | Back Directory | [Boiling point ]
542.0±42.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
2.06±0.11(Predicted) |
| Hazard Information | Back Directory | [Uses]
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2]. | [Biological Activity]
luotonin f is an alkaloid found in the aerial parts of the peganum nigellastrum bunge, a plant which has been long used in traditional chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. an efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin f from easily available starting materials. through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, kornblum oxidation, and annulations [2]. the developed approach could efficiently synthesize luntonin f and various analogues. luotonin f showed promising cytotoxicity against leukemia p-388 cells with an ic50 value of 2.3 μg/ml by stabilizing the dna topoisomerase i-dna complex [1]. | [IC 50]
Topoisomerase II | [References]
[1] liang j l, cha h c, jahng y. recent advances in the studies on luotonins[j]. molecules, 2011, 16(6): 4861-4883.
[2] zhu y, fei z, liu m, et al. direct one-pot synthesis of luotonin f and analogues via rational logical design[j]. organic letters, 2012, 15(2): 378-381. |
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