| Identification | Back Directory | [Name]
Pomalidomide-PEG3-Amine HCl salt | [CAS]
2446474-09-3 | [Synonyms]
Pomalidomide-PEG3-NH2.HCl
Thalidomide-NH-PEG3-NH2 HCl
Pomalidomide-PEG3-Amine HCl salt
Pomalidomide-PEG3-Amine hydrochloride
Pomalidomide-PEG3-C2-NH2 hydrochloride
Thalidomide-NH-PEG3-C2-NH2 hydrochloride
Pomalidomide-NH-PEG3-amine hydrochloride
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [MOL File]
2446474-09-3.mol | [Molecular Weight]
484.93 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [form ]
Solid | [color ]
Light yellow to yellow | [InChI]
1S/C21H28N4O7/c22-6-8-30-10-12-32-13-11-31-9-7-23-15-3-1-2-14-18(15)21(29)25(20(14)28)16-4-5-17(26)24-19(16)27/h1-3,16,23H,4-13,22H2,(H,24,26,27) | [InChIKey]
ALLUGXFCRRSPMS-UHFFFAOYSA-N | [SMILES]
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN)=CC=C3)=O)=O |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [Biological Activity]
Pomalidomide 4'-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand. | [IC 50]
Cereblon | [storage]
Desiccate at RT | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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