2448341-58-8

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2448341-58-8 Structure

Identification	Back Directory
[Name] Thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide, N-[3-(diethylamino)propyl]-5,9-dimethyl-8-oxo-
[CAS] 2448341-58-8
[Synonyms] Thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide, N-[3-(diethylamino)propyl]-5,9-dimethyl-8-oxo-
[Molecular Formula] C19H27N5O2S
[MDL Number] MFCD32201073
[MOL File] 2448341-58-8.mol
[Molecular Weight] 389.52

Hazard Information	Back Directory
[Uses] NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity[1].
[IC 50] UHRF1
[References] [1] Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23(9):930-940. DOI:10.1177/2472555218766278

Spectrum Detail	Back Directory
[Spectrum Detail] Thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide, N-[3-(diethylamino)propyl]-5,9-dimethyl-8-oxo-(2448341-58-8)¹HNMR

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