| Identification | Back Directory | [Name]
barakol | [CAS]
24506-68-1 | [Synonyms]
barakol
2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
3aH-Pyrano[2,3,4-de]-1-benzopyran-3a,8-diol, 2,5-dimethyl- | [Molecular Formula]
C13H12O4 | [MOL File]
24506-68-1.mol | [Molecular Weight]
232.23 |
| Hazard Information | Back Directory | [Uses]
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects[1][2][3]. | [References]
[1] Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav. 1996 Mar;53(3):753-8. DOI:10.1016/0091-3057(95)02088-8
[2] Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10(3):e24694. DOI:10.1016/j.heliyon.2024.e24694
[3] Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. J Ethnopharmacol. 2011 Sep 2;137(2):971-8. DOI:10.1016/j.jep.2011.07.013 |
|
|