| Identification | Back Directory | [Name]
2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-(2-oxo-2H-1-benzopyran-6-yl)-, (2E)- | [CAS]
2451479-66-4 | [Synonyms]
hCAXII-IN-1
2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-(2-oxo-2H-1-benzopyran-6-yl)-, (2E)- | [Molecular Formula]
C20H17NO5 | [MOL File]
2451479-66-4.mol | [Molecular Weight]
351.35 |
| Hazard Information | Back Directory | [Uses]
These compounds show selective inhibition on tumor related subtypes HCA IX and XII, and are also considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action. | [IC 50]
CA Ⅸ | [References]
[1] Swain B,et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586. DOI:10.1016/j.bmc.2020.115586 |
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