| Identification | Back Directory | [Name]
Butanedioic acid, 2-methylene-, 4-(7-octyn-1-yl) ester | [CAS]
2454181-83-8 | [Synonyms]
Itaconate-alkyne
Butanedioic acid, 2-methylene-, 4-(7-octyn-1-yl) ester
GSN,labeling,bioorthogonal,DDB1,AK2,Itaconatealkyne,Itaconation,LPS,probe,site-specific,Itaconate,ACLY,Itaconate alkyne,NRF-2,IL-1β,Inhibitor,quantitative,chemoproteomic,inhibit,Itaconate-alkyne,Raw264.7,antiinflammatory | [Molecular Formula]
C13H18O4 | [MOL File]
2454181-83-8.mol | [Molecular Weight]
238.28 |
| Chemical Properties | Back Directory | [Boiling point ]
385.4±32.0 °C(Predicted) | [density ]
1.083±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
3.83±0.11(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [storage]
Store at -20°C | [References]
[1] Wei Qin, et al. Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages. J Am Chem Soc . 2020 Jun 24;142(25):10894-10898. DOI:10.1021/jacs.9b11962 |
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