24549-12-0

292638-85-8

74-89-5

24549-12-0

Example 38: General procedure for the synthesis of methyl 3-(methylamino)propionate: methyl acrylate (10 g, 116 mmol) was dissolved in methanol (20 mL) and the solution was cooled to -20 °C. Methylamine solution (2M, dissolved in tetrahydrofuran, 90mL, 180mmol) was added slowly through the addition funnel, keeping the reaction mixture stirred at -20°C for 2 hours. After completion of the reaction, the solvent was removed under vacuum. The residue was distilled under reduced pressure (45 °C, 5 Torr) to give methyl 3-(methylamino)propionate as a colorless liquid (3.5 g, 28% yield). The product was characterized by 1H NMR (CDCl3): δ 2.44 (s, 3H), 2.52 (t, 2H, J=6.31Hz), 2.86 (t, 2H, J=6.31Hz), 3.69 (s, 3H).