| Hazard Information | Back Directory | [Uses]
PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia[1]. | [References]
[1] Serrano-Wu MH, et al. Preparation of 2-[[2-methyl-3-[[5-(methylthio)pyrimidin-2-yl]amino]propyl]amino]benzo[d]thiazoles and analogs as PCSK9 inhibitors and methods of their use. World Intellectual Property Organization, WO2020150474 A1. 2020-07-23. |
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