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Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2] | [in vivo]
Sprague–Dawley rats are fed a standard diet with 1 week, and then randomly assigned to the two groups. The control group received a normal diet (10 kcal%), while the NAFLD group is fed a high-fat diet (60 kcal%; 18 weeks)[1].
10 BAs from the NAFLD group are significantly decreased in the liver, including 4 tauro-conjugated BA species including taurolithocholic acid (TLCA), THDCA, taurodeoxycholic acid (TDCA) and tauro ω-muricholic acid (TωMCA). Furthermore, βDCA, HDCA, 6-ketoLCA, 23-nordeoxycholic acid (NorDCA), LCA and 3β-chenodeoxycholic acid (βCDCA) shows lower levels in the NAFLD group[2].
| [References]
[1] Z?hrer E, et al. Neonatal?sepsis?leads?to?early?rise?of?rare?serum?bile?acid?tauro-omega-muricholic?acid?(TOMCA).Pediatr Res.?2018 Jul;84(1):66-70. DOI:10.1038/s41390-018-0007-y
[2] Tang Y, et al. Turnover?of?bile?acids?in?liver,?serum?and?caecal?content?by?high-fat?diet?feeding?affects?hepatic?steatosis?in?rats. Biochim Biophys Acta Mol Cell Biol Lipids.?2019 Oct;1864(10):1293-1304 DOI:10.1016/j.bbalip.2019.05.016 |
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