| Hazard Information | Back Directory | [Description]
CN128 is an orally bioavailable iron chelator.1 It contains a side chain hydroxy group that acts as an alternate sacrificial glucuronidation site to alleviate metabolic inactivation at the 3-hydroxy group. CN128 increases iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload when administered at doses of 150 and 450 μmol/kg. | [References]
1. Chen, W., Yuan, X., Li, Z., et al. CN128: A new orally active hydroxypyridinone iron chelator J. Med. Chem. 63(8),4215-4226(2020). |
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