| Identification | Back Directory | [Name]
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid | [CAS]
2458-08-4 | [Synonyms]
Einecs 219-542-6
12-Oxocholic acid
12-Ketochenodeoxycholic acid
Ursodeoxycholic Acid Impurity 23
Chenodeoxycholic Acid Impurity 10
3,7-Dihydroxy-12-oxocholanoic acid
3α,7α-Dihydroxy-12-oxocholanic acid
5β-CHOLANIC acid-3α, 7α-DIOL-12-ONE
3α,7α-Dihydroxy-12-oxo-5β-cholanic acid
3α,7α-Dihydroxy-12-oxo-5β-cholan-24-oic acid
Cholic Acid Impurity 8 (12-Oxochenodeoxycholic Acid)
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
Cholan-24-oic acid, 3,7-dihydroxy-12-oxo-, (3 alpha,5 beta,7 alpha)- | [EINECS(EC#)]
219-542-6 | [Molecular Formula]
C24H38O5 | [MDL Number]
MFCD00134876 | [MOL File]
2458-08-4.mol | [Molecular Weight]
406.56 |
| Chemical Properties | Back Directory | [Boiling point ]
583℃[at 101 325 Pa] | [density ]
1.18[at 20℃] | [vapor pressure ]
0Pa at 20℃ | [storage temp. ]
-20°C | [solubility ]
Chloroform: Slightly Soluble
Methanol: Slightly Soluble | [form ]
Solid | [pka]
5[at 20 ℃] | [color ]
White to off-white | [Water Solubility ]
4.698mg/L at 25℃ | [LogP]
2.97 at 20℃ |
| Hazard Information | Back Directory | [Uses]
12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). Cholodeoxycholic acid is used to cholesterol gallstones and has chemotherapeutic properties that dissolve gallstones[1]. | [Definition]
ChEBI: 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanic acid is an oxo-5beta-cholanic acid. It is a conjugate acid of a 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate. | [Flammability and Explosibility]
Nonflammable | [References]
[1] Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10(1–2), 107–112. |
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