| Hazard Information | Back Directory | [Uses]
PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research[1]. | [IC 50]
PI3Kβ: 7.22 μM (IC50); PI3Kδ: 10.94 μM (IC50); PI3Kα: 13.98 μM (IC50) | [References]
[1] Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051. DOI:10.1016/j.bioorg.2020.104051 |
|
|