| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[4-[[2-[(1H-benzimidazol-2-ylmethyl)thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]-3-(6-bromo-2-pyridinyl)-, (2E)- | [CAS]
2459892-41-0 | [Synonyms]
Antiproliferative agent-5
2-Propen-1-one, 1-[4-[[2-[(1H-benzimidazol-2-ylmethyl)thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]-3-(6-bromo-2-pyridinyl)-, (2E)- | [Molecular Formula]
C28H21BrN8OS | [MOL File]
2459892-41-0.mol | [Molecular Weight]
597.49 |
| Hazard Information | Back Directory | [Uses]
Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer[1]. | [References]
[1] Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway.?Eur J Med Chem. 2020;203:112630. DOI:10.1016/j.ejmech.2020.112630 |
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